Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex
Summary: Ubiquitination controls numerous cellular processes, and its deregulation is associated with many pathologies.The Nse1 subunit in the Smc5/6 complex contains caruso milk thistle a RING domain with ubiquitin E3 ligase activity and essential functions in genome integrity.However, Nse1-dependent ubiquitin targets remain elusive.Here, we use l